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E-mail:
Office:
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nancy.reich@stonybrook.edu
(631) 632-8650
(631) 632-9797

Lab Members

Publications

Research

Cytokine Signaling, Gene Expression, Immune Defense, Cancer

Immune defense, differentiation, programmed cell death, and malignancy are all influenced by extracellular cytokines. Our research centers on the action of a subset of cytokines that stimulate Janus tyrosine kinases (JAKs) and signal transducers and activators of transcription (STATs). Activated JAK-STAT pathways rapidly transduce signals from outside the cell into the nucleus to regulate gene expression. Although the JAK-STAT cytokines use similar signal transduction pathways, their biological effects are quite diverse. For example, interferons confer resistance to viral infections, whereas interleukin-6 promotes inflammation and malignancy. We are currently exploring mouse models of viral infection and pancreatic cancer to identify molecular mechanisms that can be used to combat these diseases.

Petrenko, O. V. Kirillov, S. D’Amico, and N.C. Reich (2025). Intratumor heterogeneity in KRAS signaling shapes treatment resistance. iScience. doi.org/10.1016/j.isci.2024.111662.

Li, J, S. D’Amico, V. Kirillov, O. Petrenko, and N.C. Reich (2023). Oncogenic Dependency Plays a Dominant Role in the Immune response to Cancer. Proc. Natl. Acad. Sci. USA. doi:10.1073/pnas.2308635120.

D’Amico, S., V. Kirillov, O. Petrenko, and N.C. Reich (2023). STAT3 is a Genetics Modifier of TGF-beta Induced EMT in KRAS Mutant Pancreatic Cancer. eLife. doi:10.7554/eLife.92559.1.

Sohn, S-Y., Hearing, J., Mugavero,J., Kirillov,V., Gorbunova, E., Helminiak,L., Mishra, S., Mackow, E., Hearing, P., Reich, N.C. and Kim, H. (2021). Interferon-lambda Intranasal Protection and Differential Sex Pathology in a Murine Model of SARS-CoV-2 Infection. mBio. Nov 2;12(6):e0275621.

Ischenko, I., S. D'Amico, M. Rao, J. Lin, M.J. Hayman, S. Powers, O. Petrenko and N.C. Reich. KRAS drives immune evasion in a genetic model of pancreatic cancer (2021). Nature Communications, Mar 5;12(1):1482.

Petrenko, O., J. Li, V. Cimica, P. Mena-Taboada, HY., Shin, S. D'Amico and N.C. Reich. IL-6 promotes MYC-induced B cell lymphomagenesis independent of STAT3 (2021). PLOS One, Mar 2; 16(3): e0247394.

Prokunia-Olsson, L., N. Alphonse, R.E. Dickerson, J.E. Durbin, J.S. Glenn, R. Hartmann, S.V. Kotenko, H.M. Lazear, T.R. O’Brien, C. Odendall, I.O. Onabajo, H. Pionkivska, D.M. Santer, N.C. Reich, A. Wack,and I. Zanoni (2020) COVID-19 and emerging viral infections: The case for interferon lambda. Journal of Experimental Medicine, 217(5):e20299653.

D’Amico, S., J. Shi, B.L. Martin, H.C. Crawford, O. Petrenko, and N.C. Reich (2018) STAT3 is a master regulator of epithelial identitiy and KRAS-driven tumorigenicity. Genes & Development Sep 1;32(17-18):1175-1187. 

Stawowczyk, M., S. Naeem, V. Montoya, D.P. Baker, J. Konopka  and N.C. Reich (2018) Pathogenic effects of IFIT2 and interferon-β during fatal systemic Candida albicans infection, mBio, Apr 17;9(2): 365-18.

Foreman, H-C, J. Armstrong, A. Santana, L.T. Krug, and N.C. Reich (2017) The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression. Journal of Biological Chemistry, 292:16257-16266.

Reddy, S., HC. Foreman, T. Ozula, GH. Park, V. Poli, N.C. Reich, and L.T. Krug (2016) Ablation of STAT3 in the B cell compartment restricts gammaherpesvirus latency in vivo, mBio, v.7(4):e00723-16.

Shin, HY. and N.C. Reich (2013) Dynamic trafficking of STAT5 depends on an unconventional nuclear localization signal,Journal Cell Science, 126: 3333-3343.

Reich, N.C. (2013) STATs get their move on. JAKSTAT, 2:e27080

Gao, Y., V. Cimica, and N.C. Reich (2012) Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3, Journal of Biological Chemistry, 287: 20904-12.

Foreman, H-C, S. Van Scoy, T-F. Cheng, and N.C. Reich, (2012). Activation of Interferon Regulatory Factor 5 in Innate Immune Signaling by Site Specific Phosphorylation, PLoS One. 2012;7(3):e33098

Brzostek-Racine, S., C. Gordon, S. Van Scoy , and N.C. Reich (2011). The DNA Damage Response Induces IFN. Journal of Immunology, 187:5336-45.

Cimica, V., H.C. Chen, J.K. Iyer, and N.C. Reich (2011) Dynamics of the STAT3 Transcription Factor: Nuclear Import Dependent on Ran and Importin-b1, PLoS One 6(5):e20188.

Stawowczyk, M., Van Scoy, S, Kumar, PK and Reich NC 2011. The interferon stimulated gene 54 promotes apoptosis. Journal of Biological Chemistry, 286:7257-66.

Chen, HC and Reich NC 2010. Live cell imaging reveals continuous STAT6 nuclear trafficking. Journal of Immunology 185:64-70.

Reich, NC 2009. STAT3 revs up the powerhouse. Science Signaling 2:pe61.

Andersen, JS., VanScoy, S, Cheng, T-F,  Gomez, D and Reich, NC.  2008. Genes and Immunity, 9:168-175.

Iyer, J and Reich, NC.  2008. , FASEB J., 22:391-40.

Reich NC, Liu L. 2006. Nat Rev Immunol. Aug;6(8):602-12.

Cheng TF, Brzostek S, Ando O, Van Scoy S, Kumar KP, Reich NC. 2006. J Immunol. Jun 15;176(12):7462-70.

Liu L, Gao Y, Qiu H, Miller WT, Poli V, Reich NC. 2006. Oncogene. Aug 10;25(35):4904-12.

Gilbert, M.M., B.K. Weaver, and N.C. Reich. 2005. , 122: 939-948.

Liu, L., K. McBride, and N.C. Reich. 2005. , Proc Natl Acad Sci USA, 102:8150-8155.

Banninger, G. and N.C. Reich 2004. . J. Biol. Chem.. 279: 39199-206.

Gomez, D. and N.C. Reich, 2003., J. Immunology 170: 5373-5381

McBride, K., G. Banninger, C. McDonald and N.C. Reich. 2002. , EMBO J., in press

Faruqi. T.R., D. Gomez, X. Bustelo, D. Bar-Sagi and N.C. Reich. 2001. . Proc Natl Acad Sci USA, 98:9014-9019

Weaver, B., O. Ando, K.P. Kumar and N.C. Reich. 2001. . FASEB J., 15:501-551

McBride, K.E., C. McDonald, and N.C. Reich. 2000. EMBO J. 19:6196-6206.

Kumar, K.P., K. McBride, B. Weaver, C. Dingwall, and N.C. Reich. 2000. . Mol. & Cell. Biol. 20:4159-4168.

McDonald, C. and N.C. Reich. 1999. J. Interferon & Cytokine Res. 19:711-722.

Weaver, B.K., K.P. Kumar and N.C. Reich. 1998. Mol. & Cell. Biology 18:359-368.

Martinez-Moczygemba, M., M.J. Gutch, D. French and N.C. Reich. 1997. . J. Biol. Chem. 272:200070-200076.

Kotanides, H. and N.C. Reich. 1996. J. Biol. Chem. 271:25555-25561.

Gilmour, K.C., R. Pine and N.C. Reich. 1995. Proc. Natl. Acad. Sci. USA 92:10772-10776. 

Daly, C. and N.C. Reich. 1995. . J. Biol. Chem. 270:23739-23746. 

Gilmour, K.C. and N.C. Reich. 1994. Proc. Natl. Acad. Sci. USA 91:6850-6854. 

Kotanides, H. and N.C. Reich. 1993. Science 262:1265-1267. 

Gutch, M.J., C. Daly, and N.C. Reich. 1992. Proc. Natl. Acad. Sci. USA 89:11411-11415.

Reich, N.C., B. Evans, D. Levy, D. Fahey, E. Knight, Jr, and J.E. Darnell, Jr. 1987. Proc. Natl. Acad. Sci. USA 84:6394-6398.

Reich, N.C. and A.J. Levine. 1984. Nature 308:199-201.

See for a complete list of current publications.