Kelly DeMarco
Education:
B.S. University of Massachusetts Amherst (2021)
Advisor:
TBA
Graduate Program:
TBA
Research Interests:
Cancer immunology, Cellular senescence, Cancer metabolism
Publications:
Parikh C, DeMarco KD, Ma B, et al. Multiplexed cytokine and antigen mRNA administration generates durable anti-tumor immunity in pancreatic cancer. Nature Communications. Submitted.
Zhou L, DeMarco KD, Murphy KC, et al. Senolysis is chemopreventive and reverses immune suppression to potentiate immunotherapy in advanced prostate cancer. Cancer Discovery. Under Revision.
Chowdhury SR, Parikh CN, Kaur AH, DeMarco KD, et al. PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors. Proc. Natl. Acad. Sci. September 22, 2025.
Murphy KC, DeMarco KD, Zhou L, et al. MYC and p53 alterations cooperate through VEGF signaling to repress cytotoxic T cell and immunotherapy responses in prostate cancer. Cancer Research. September 3, 2025.
Chibaya L*, DeMarco KD*, Lusi CF, et al. Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer. Science Translational Medicine (*co-first author). August 28, 2024.
Chibaya L, Murphy KC, DeMarco KD, et al. EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance. Nat Cancer. May 4, 2023.
Conference Posters/Presentations:
Poster: Chibaya L*, DeMarco KD*, Lusi CF, et al. Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer. October 2, 2024. UMass Chan Cancer Biology Research Program Retreat, Worcester, MA.
Poster: Chibaya L*, DeMarco KD*, Lusi CF, et al. Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer. September 16, 2024. American Association of Cancer Research Conference on Advances in Pancreatic Cancer Research, Boston, MA.
Oral: Chibaya L*, DeMarco KD*, Lusi CF, et al. Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer. June 7, 2024. UMass Chan GI Research Conference, Worcester, MA.
Awards:
Certificate of Achievement for Outstanding Poster Presentation at the UMass Chan Cancer Biology Research Program Retreat, October 2, 2024.